Background: The aim of this study was to evaluate the antidiabetic activity of Mimusops elengi L. against dexamethasone induced diabetes in mice. As we all known, glucocorticoids can induce insulin resistance when they are administered to human or experimental animals during excess condition. Materials and Methods: Normal control group received equivalent amount of phosphate buffer saline, and 54 mice were rendered hyperglycemic by daily administration of a pre standardized dose of dexamethasone for consecutive 7 days and then divided in to nine groups of six each. Blood samples were collected and serum insulin was estimated. Biochemical estimation of Plasma glucose and serum triglyceride, serum cholesterol, Atherogenic index was done using standard diagnostic kits. Hepatic antioxidant as well as Glycogen content from liver and calf muscle was estimated after sacrificing animals on day 22. Three fractions from methanolic extract were screened. Results: Group treated with F1 (Aqueous fraction) and F2 (n-Butanol fraction) 100 mg/kg were found to be highly significant as compared with dexamethasone control group. Conclusion: Thus from the results obtained in the present investigation we can conclude that F1 and F2 may prove to be useful in treating insulin resistance as F1 and F2 is able to produce glycemic control, and increase insulin sensitivity. F1 and F2 is also endowed with in vivo antioxidant activity along with the ability to increase glycogenesis which can prove beneficial in the management of complications of insulin resistance like diabetes and diabetic complications.
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